USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P41250 USC-OGP 2-DE database:  P41250 P41250 General information about the entry View entry in simple text format Entry name SYG_HUMAN Primary accession number P41250 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glycine--tRNA ligase; EC=3.6.1.17 {ECO:0000269|PubMed:19710017}; EC=6.1.1.14 {ECO:0000269|PubMed:17544401}; AltName: Full=Diadenosine tetraphosphate synthetase; Short=AP-4-A synthetase; AltName: Full=Glycyl-tRNA synthetase; Short=GlyRS;. Gene name Name=GARS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1120: pI=6.09; Mw=84978 SPOT OGP-1121: pI=5.77; Mw=83686 SPOT OGP-1124: pI=5.86; Mw=80748 Cross-references UniProtKB/Swiss-Prot P41250; SYG_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYG_HUMAN Primary accession number P41250 Secondary accession number(s) B3KQA2 B4DIA0 Q969Y1 Sequence was last modified on  November 30, 2010 (version 3) Annotations were last modified on  March 15, 2017 (version 178) Name and origin of the protein Description RecName: Full=Glycine--tRNA ligase; EC=3.6.1.17 {ECO:0000269|PubMed:19710017}; EC=6.1.1.14 {ECO:0000269|PubMed:17544401}; AltName: Full=Diadenosine tetraphosphate synthetase; Short=AP-4-A synthetase; AltName: Full=Glycyl-tRNA synthetase; Short=GlyRS; Gene name Name=GARS Encoded on Name=GARS Keywords 3D-structure; Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Cell projection; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Disease mutation; Hydrolase; Ligase; Mitochondrion; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D30658; BAA06338.1; -; mRNA EMBL U09510; AAA86443.1; ALT_INIT; mRNA EMBL AK074524; BAG51964.1; -; mRNA EMBL AK295490; BAG58412.1; -; mRNA EMBL AC005154; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC006969; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC004976; AAC71652.1; -; Genomic_DNA EMBL BC007722; AAH07722.1; -; mRNA EMBL BC007755; AAH07755.1; -; mRNA EMBL U09587; AAA57001.1; ALT_INIT; mRNA CCDS CCDS43564.1; -; . PIR A55314; A55314; . RefSeq NP_001303701.1; NM_001316772.1; . RefSeq NP_002038.2; NM_002047.3; . UniGene Hs.404321; -; . PDB 2PME; X-ray; 2.90 A; A=55-739 PDB 2PMF; X-ray; 2.85 A; A=55-739 PDB 2Q5H; X-ray; 3.00 A; A=55-739 PDB 2Q5I; X-ray; 2.80 A; A=55-739 PDB 2ZT5; X-ray; 2.50 A; A=55-739 PDB 2ZT6; X-ray; 3.08 A; A=55-739 PDB 2ZT7; X-ray; 2.70 A; A=55-739 PDB 2ZT8; X-ray; 3.35 A; A=55-739 PDB 2ZXF; X-ray; 3.40 A; A=55-739 PDB 4KQE; X-ray; 2.74 A; A=55-739 PDB 4KR2; X-ray; 3.29 A; A=114-739 PDB 4KR3; X-ray; 3.24 A; A=114-739 PDB 4QEI; X-ray; 2.88 A; A=118-739 PDB 5E6M; X-ray; 2.93 A; A/B=55-739 PDBsum 2PME; -; . PDBsum 2PMF; -; . PDBsum 2Q5H; -; . PDBsum 2Q5I; -; . PDBsum 2ZT5; -; . PDBsum 2ZT6; -; . PDBsum 2ZT7; -; . PDBsum 2ZT8; -; . PDBsum 2ZXF; -; . PDBsum 4KQE; -; . PDBsum 4KR2; -; . PDBsum 4KR3; -; . PDBsum 4QEI; -; . PDBsum 5E6M; -; . ProteinModelPortal P41250; -; . SMR P41250; -; . BioGrid 108887; 89; . DIP DIP-50471N; -; . IntAct P41250; 19; . MINT MINT-1395438; -; . STRING 9606.ENSP00000373918; -; . DrugBank DB00145; Glycine; . iPTMnet P41250; -; . PhosphoSitePlus P41250; -; . SwissPalm P41250; -; . BioMuta GARS; -; . DMDM 313104283; -; . EPD P41250; -; . MaxQB P41250; -; . PaxDb P41250; -; . PeptideAtlas P41250; -; . PRIDE P41250; -; . DNASU 2617; -; . Ensembl ENST00000389266; ENSP00000373918; ENSG00000106105; . GeneID 2617; -; . KEGG hsa:2617; -; . UCSC uc003tbm.4; human; . CTD 2617; -; . DisGeNET 2617; -; . GeneCards GARS; -; . GeneReviews GARS; -; . H-InvDB HIX0006570; -; . HGNC HGNC:4162; GARS; . HPA HPA017896; -; . HPA HPA019097; -; . MalaCards GARS; -; . MIM 600287; gene; . MIM 600794; phenotype; . MIM 601472; phenotype; . neXtProt NX_P41250; -; . OpenTargets ENSG00000106105; -; . Orphanet 99938; Autosomal dominant Charcot-Marie-Tooth disease type 2D; . Orphanet 139536; Distal hereditary motor neuropathy type 5; . PharmGKB PA28575; -; . eggNOG KOG2298; Eukaryota; . eggNOG COG0423; LUCA; . GeneTree ENSGT00390000016949; -; . HOGENOM HOG000242015; -; . HOVERGEN HBG036190; -; . InParanoid P41250; -; . KO K01880; -; . OMA ERFGWVE; -; . OrthoDB EOG091G02U0; -; . PhylomeDB P41250; -; . TreeFam TF343504; -; . BRENDA 6.1.1.14; 2681; . Reactome R-HSA-379716; Cytosolic tRNA aminoacylation; . Reactome R-HSA-379726; Mitochondrial tRNA aminoacylation; . ChiTaRS GARS; human; . EvolutionaryTrace P41250; -; . GeneWiki Glycine%E2%80%94tRNA_ligase; -; . GenomeRNAi 2617; -; . PMAP-CutDB P41250; -; . PRO PR:P41250; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000106105; -; . CleanEx HS_GARS; -; . ExpressionAtlas P41250; baseline and differential; . Genevisible P41250; HS; . GO GO:0030424; C:axon; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IBA:GO_Central; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0030141; C:secretory granule; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004081; F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; IDA:UniProtKB; . GO GO:0004820; F:glycine-tRNA ligase activity; IDA:UniProtKB; . GO GO:0046983; F:protein dimerization activity; IDA:UniProtKB; . GO GO:0015966; P:diadenosine tetraphosphate biosynthetic process; IDA:UniProtKB; . GO GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . CDD cd00774; GlyRS-like_core; 1; . Gene3D 1.10.287.10; -; 1; . Gene3D 3.40.50.800; -; 1; . InterPro IPR002314; aa-tRNA-synt_IIb; . InterPro IPR006195; aa-tRNA-synth_II; . InterPro IPR004154; Anticodon-bd; . InterPro IPR027031; Gly-tRNA_synthase/POLG2; . InterPro IPR033731; GlyRS-like_core; . InterPro IPR009068; S15_NS1_RNA-bd; . InterPro IPR002315; tRNA-synt_gly; . InterPro IPR000738; WHEP-TRS_dom; . PANTHER PTHR10745; PTHR10745; 1; . Pfam PF03129; HGTP_anticodon; 1; . Pfam PF00587; tRNA-synt_2b; 1; . Pfam PF00458; WHEP-TRS; 1; . PRINTS PR01043; TRNASYNTHGLY; . SMART SM00991; WHEP-TRS; 1; . SUPFAM SSF47060; SSF47060; 1; . SUPFAM SSF52954; SSF52954; 1; . TIGRFAMs TIGR00389; glyS_dimeric; 1; . PROSITE PS50862; AA_TRNA_LIGASE_II; 1; . PROSITE PS00762; WHEP_TRS_1; 1; . PROSITE PS51185; WHEP_TRS_2; 1; .

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